Xbira 500mg: Top-Tier Oncology Export- UNNATI PHARMAX

Product introduction

Xbira 500 Tablet is used in the treatment of cancer of the prostate gland. It may also be used to treat other conditions, as determined by the doctor. It is sometimes used with certain other medicines as part of combination chemotherapy.

Xbira 500 Tablet should not be taken on an empty stomach. Taking it with food may cause side effects. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include vomiting, decreased potassium level in blood, edema (swelling), decreased white blood cell count, fatigue and increased liver enzymes. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. Other than this, yellowing of skin, loss of appetite, shortness of breath, dark urine and nausea can happen, which indicate some liver problem. Your doctor might check you for liver function, blood pressure, and the level of potassium in your blood.

Before taking it, tell your doctor if have high blood pressure, heart problem, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. It may harm your baby. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. You may be asked for regular monitoring of blood glucose level while on treatment.

There is a Patient Support Program/Patient Assistance Program available in India for this medicine, being managed by Tata 1mg. Please contact your prescribing doctor to know more about the same. You may also call on (1800-102-1618) for more details.

Uses of Xbira Tablet

Prostate cancer

Benefits of Xbira Tablet

In Prostate cancer

Prostate gland is a small walnut-sized gland that produces a fluid called seminal fluid that nourishes and transports sperms in males. The most common symptom of prostate cancer is difficulty with urination, but sometimes there are no symptoms at all. Xbira 500 Tablet decreases or stops the growth of cancer cells by decreasing the amount of testosterone (natural hormone in males) in men. This also relieves difficulty in passing urine and makes it easier for you to urinate.

Side effects of Xbira Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Xbira

Edema (swelling)
Vomiting
Decreased potassium level in blood
Fatigue
Anemia (low number of red blood cells)
Urinary tract infection
Diarrhea
High blood pressure
Cough
Joint swelling
Nausea
Hot flashes
Headache
Increased glucose level in blood

How to use Xbira Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Xbira 500 Tablet is to be taken empty stomach.

How Xbira Tablet works

Xbira 500 Tablet works by blocking an enzyme called CYP17, which is involved in the production of androgens (male hormones like testosterone). Since many prostate cancers rely on these hormones to grow, reducing their levels helps slow down or stop the cancer’s progression. Essentially, Xbira 500 Tablet cuts off the fuel supply that the cancer needs to thrive.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Xbira 500 Tablet. Please consult your doctor.

Pregnancy

UNSAFE

Xbira 500 Tablet is highly unsafe to use during pregnancy. Seek your doctor’s advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

Breast feeding

UNSAFE

Xbira 500 Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

SAFE

Xbira 500 Tablet does not usually affect your ability to drive.

Kidney

CAUTION

Xbira 500 Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Xbira 500 Tablet may be needed. Please consult your doctor.

Liver

CAUTION

Xbira 500 Tablet should be used with caution in patients with liver disease. Dose adjustment of Xbira 500 Tablet may be needed. Please consult your doctor.

What if you forget to take Xbira Tablet?

If you miss a dose of Xbira 500 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Quick tips

Xbira 500 Tablet is usually taken with another medicine called prednisolone to reduce unwanted side effects.
It should be taken on an empty stomach, either one hour before or at least two hours after a meal.
Always use effective birth control measures to prevent pregnancy while taking this medicine.
Your doctor may regularly monitor your liver function, blood pressure, and the level of potassium in your blood while you are having treatment with this medicine.

FAQs

How to take Xbira 500 Tablet?

Xbira 500 Tablet should be taken on an empty stomach with water 1 hour before eating or at least 2 hours after eating. Taking it with food may cause increased and variable levels of Xbira 500 Tablet in your blood, which can be harmful. Remember not to crush or chew it.

Can Xbira 500 Tablet cure prostate cancer?

Xbira 500 Tablet does not cure cancer, but helps in prolonging and improving the life of the patient. Moreover, when prostate cancer is treated with Xbira 500 Tablet, then the frequency of fractures is relatively lower. Similarly, the increase in pain is less common with Xbira 500 Tablet.

Is Xbira 500 Tablet a chemotherapy drug?

Xbira 500 Tablet is a hormonal treatment, not a chemotherapy drug. It is used to treat prostate cancer in adult men that has spread to other parts of the body. Xbira 500 Tablet stops your body from making testosterone. This can slow down the growth of prostate cancer.

Why do I need to take prednisolone with Xbira 500 Tablet?

Your doctor will always prescribe prednisolone with Xbira 500 Tablet. Taking these two medicines together lowers the risk of getting high blood pressure, fluid retention (having too much water in your body), or having reduced levels of potassium in your blood, which can occur due to Xbira 500 Tablet.

Does Xbira 500 Tablet affect liver?

Xbira 500 Tablet can cause severe liver problems. In very rare cases, Xbira 500 Tablet may even cause failure of the liver to function (called acute liver failure), which can even lead to death. Tell your doctor if you experience yellowing of the skin or eyes, darkening of the urine, or severe nausea or vomiting, as these could be signs or symptoms of liver problems.

How frequently should the liver investigations be done?

Liver enzymes should be measured before starting the treatment, every two weeks for the first three months of the treatment, and monthly thereafter. If you develop clinical symptoms or signs suggestive of liver toxicity, liver enzymes should be measured immediately. If the liver enzyme levels are increased beyond certain levels, your doctor may temporarily discontinue the treatment with Xbira 500 Tablet.

Reference:-

U.S. Food and Drug Administration (FDA)
- Abiraterone Acetate (Zytiga) drug label: https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/202379lbl.pdf
European Medicines Agency (EMA)
- Zytiga (brand name Abiraterone Acetate) EPAR: https://www.ema.europa.eu/en/medicines/human/EPAR/zytiga
National Institutes of Health (NIH)
- National Cancer Institute (NCI) definition: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/abiraterone-acetate
- PubMed Central (PMC) – Example research paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018245/
ClinicalTrials.gov
- Example clinical trial for Abiraterone Acetate: https://clinicaltrials.gov/study/NCT00887198

Brand Name	Xbira 500mg Tablet
Generic Name	Abiraterone Acetate
Strength	500 mg
Drug Class	Androgen Biosynthesis Inhibitor / Anti-androgen
Therapeutic Class	Anti-neoplastic / Anti-cancer agents
Mechanism of Action	Xbira (Abiraterone Acetate) works by inhibiting the enzyme CYP17, which plays a critical role in the production of androgens (male hormones) in the testes, adrenal glands, and prostate tumor tissue. By significantly reducing the levels of these hormones, the medication starves the prostate cancer cells of the fuel they need to grow and spread, thereby slowing the progression of the disease.

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Xbira 500mg Abiraterone Acetate (Zytiga) for Prostate Cancer Treatment

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Product introduction

Uses of Xbira Tablet