Trilfuridine Tipiracil ( LONSURF )

LONSURF (Trifluridine Tipiracil) is an oral prescription medication used in the treatment of certain advanced cancers, primarily metastatic colorectal cancer (mCRC) and metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma. It combines Trifluridine, a nucleoside analog that disrupts cancer cell DNA function, and Tipiracil, an enzyme inhibitor that increases Trifluridine’s effectiveness in the body.

International Brand Name: LONSURF
Generic Name: Trifluridine and Tipiracil Tablets
Strengths Available: 15 mg/6.14 mg and 20 mg/8.19 mg per tablet
Dosage Form: Film-coated tablets
Packing: Blister packs or bottles (varies by manufacturer)
Manufacturer: Servier Pharmaceuticals (global), Taiho Pharmaceutical Co., Ltd. (Japan)

Indications

LONSURF is prescribed for:

• Adults with metastatic colorectal cancer previously treated with chemotherapy and targeted therapy.

• Adults with metastatic gastric or gastroesophageal junction adenocarcinoma after prior systemic therapy.

How It Works

• Trifluridine: Integrates into cancer cell DNA, preventing replication.

• Tipiracil: Slows breakdown of Trifluridine, maintaining therapeutic levels.

Dosage & Administration

• Usually taken orally twice daily, after morning and evening meals, for 5 days a week over 2 weeks, followed by a 2-week rest period (1 cycle = 28 days).

• Dose adjustments may be necessary based on patient tolerance and medical advice.

Side Effects

Common side effects may include:

• Fatigue

• Nausea and vomiting

• Diarrhea

• Loss of appetite

• Low blood counts (neutropenia, anemia, thrombocytopenia)

Seek immediate medical attention for signs of infection, unusual bleeding, or severe weakness.

International Availability

LONSURF is available in multiple countries including USA, Europe, Japan, Australia, India, and Southeast Asia. For patients in countries where LONSURF is not readily accessible, Palmer Wellness Hub assists in secure international sourcing with proper prescription and import documentation.

Important Note

This medicine should only be taken under the supervision of a qualified oncologist. Always follow your healthcare provider’s dosage instructions and monitoring guidelines.

Disclaimer: The information provided here is for educational purposes only and is not a substitute for professional medical advice. Please consult your doctor before starting or changing any cancer treatment.

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Reffer : https://www.fda.gov.ph/