Sorafenib 200mg Tablets – Targeted Anti-Cancer Therapy

🔬 About Sorafenib 200mg Tablets

Sorafenib is a powerful oral cancer medication used for the treatment of:

• Hepatocellular Carcinoma (HCC) – primary liver cancer

• Renal Cell Carcinoma (RCC) – advanced kidney cancer

• Differentiated Thyroid Carcinoma (DTC) – refractory to radioactive iodine

Sorafenib belongs to a class of drugs called multi-kinase inhibitors, which work by blocking tumor cell proliferation and angiogenesis (the formation of new blood vessels that supply the tumor).

💊 Key Uses:

• Liver Cancer (HCC) – primary line of therapy

• Advanced Kidney Cancer (RCC)

• Thyroid Cancer not responsive to radioiodine therapy

🧬 How Sorafenib Works:

It targets multiple proteins in cancer cells and blood vessel cells, inhibiting tumor growth and cutting off blood supply to tumors. This helps in slowing progression and improving survival rates in patients with advanced-stage cancer.

✅ Why Choose Unnatipharmax?

• Authentic Oncology Medicines

• Certified & verified pharmaceutical sourcing

• Fast and discreet global shipping

• Dedicated support team for dosage queries and prescription validation

📦 Strength & Pack Sizes:

• Sorafenib 200mg Tablets

• Common pack: 30 or 120 tablets (based on manufacturer)

• Available from top brands like Natco, Cipla, Hetero, Dr. Reddy’s

⚠️ Usage & Precaution:

• Take exactly as prescribed by your oncologist

• Typically taken twice a day (every 12 hours)

• Do not crush or chew

• Common side effects: fatigue, diarrhea, weight loss, hypertension

• Not recommended during pregnancy

🧴 Storage Instructions:

• Store at room temperature (15–30°C)

• Protect from moisture and direct sunlight

• Keep out of reach of children

Frequently Asked Questions (FAQ) for Sorafenib 200mg Tablets 

Understanding Sorafenib and Its Use

1. What is Sorafenib and what is it used for in the Philippines?

Sorafenib is an oral targeted therapy drug, classified as a multi-kinase inhibitor. In the Philippines, oncologists prescribe it to treat certain types of advanced cancer, including:

• Hepatocellular Carcinoma (HCC), the most common form of primary liver cancer.
• Advanced Renal Cell Carcinoma (RCC), a type of kidney cancer.
• Differentiated Thyroid Cancer (DTC) that is progressive and no longer responds to radioactive iodine therapy.

2. How does Sorafenib work against cancer?

Sorafenib targets and blocks several specific proteins (kinases) that are involved in two key processes: cancer cell growth (proliferation) and the development of new blood vessels that feed a tumor (angiogenesis). By blocking these pathways, Sorafenib helps to slow down or stop the growth and spread of the cancer.

3. Is Sorafenib a traditional chemotherapy drug?

No, Sorafenib is a targeted therapy. Unlike traditional chemotherapy, which attacks all rapidly dividing cells, Sorafenib is designed to interfere with specific molecular targets that are more crucial for the cancer’s survival. This leads to a different set of side effects.

4. What are the common brand names for Sorafenib in the Philippines?

The original innovator brand is Nexavar®, manufactured by Bayer. This is the most widely known brand globally and in the Philippines. High-quality generic versions of Sorafenib may also be registered and available through authorized channels. Your oncologist will prescribe the appropriate medication for you.

Dosage and Administration

5. What is the standard dose of Sorafenib?

The standard dose for adults is 400 mg (two 200 mg tablets) taken twice a day. Your oncologist may adjust this dose based on how you tolerate the side effects.

6. How should I take my Sorafenib tablets?

Sorafenib should be taken on an empty stomach, at least 1 hour before or 2 hours after a meal. If you must take it with food, it should be with a low-fat or moderate-fat meal, not a high-fat one.

7. Why is it important to avoid taking Sorafenib with a high-fat meal?

A high-fat meal can significantly decrease the absorption of Sorafenib into your bloodstream, making the medication much less effective. To get the full benefit of your treatment, you must follow the instructions about taking it on an empty stomach or with a low-fat meal.

8. What should I do if I miss a dose?

If you miss a dose, skip the missed dose completely and take your next dose at the regularly scheduled time. Do not take an extra dose to make up for the missed one.

9. How long will I need to be on this treatment?

Sorafenib is typically taken for as long as it continues to be effective in controlling your cancer and as long as the side effects are manageable. This is a decision you and your oncologist will make together based on regular monitoring.

Side Effects and Management

10. What are the most common side effects of Sorafenib?

The most common side effects are Hand-Foot Skin Reaction (HFSR), diarrhea, fatigue, rash, hair thinning, high blood pressure (hypertension), and loss of appetite.

11. What is Hand-Foot Skin Reaction (HFSR) and why is it so common with Sorafenib?

HFSR is a hallmark side effect of Sorafenib, causing redness, swelling, tenderness, pain, or blistering on the palms of the hands and soles of the feet. It occurs because the drug can affect the small blood vessels and skin cells in these areas.

12. How can I prevent or manage HFSR?

Start preventative care early. Use thick, alcohol-free moisturizers (emollients) on your hands and feet daily. Wear comfortable, well-fitting footwear. Avoid hot water and activities that cause friction on your hands and feet. Inform your doctor immediately if it develops, as they may recommend specific creams or a dose adjustment.

13. Does Sorafenib cause high blood pressure (hypertension)?

Yes, high blood pressure is a common side effect. Your oncologist will monitor your blood pressure regularly, especially during the first 6 weeks of treatment, and will prescribe medication to control it if necessary.

14. How can I manage common side effects like diarrhea and fatigue?

For diarrhea, your doctor can prescribe anti-diarrheal medication. Stay well-hydrated. For fatigue, try to balance periods of rest with light activity (like short walks), prioritize your daily tasks, and don’t be afraid to ask for help from family and friends.

15. Are there any serious side effects I should be aware of?

Yes. While less common, serious side effects can include severe bleeding (hemorrhage), heart problems (cardiac ischemia/infarction), severe high blood pressure, and a rare risk of developing a hole in the stomach or intestines (GI perforation).

Safety, Monitoring, and Access in the Philippines

16. How will my oncologist in the Philippines monitor my health?

You will have regular check-ups which include physical exams, blood pressure monitoring, and blood tests to check your liver function, kidney function, and blood cell counts. You will also have imaging scans (like CT or MRI) to see how the cancer is responding to the treatment.

17. Should I stop taking Sorafenib before a planned surgery?

Yes. Sorafenib can interfere with wound healing. You must inform your surgeon and oncologist that you are taking Sorafenib well before any planned surgery. They will likely advise you to stop taking it for a specific period before and after the procedure.

18. Can Sorafenib be taken during pregnancy?

No. Sorafenib can cause serious harm to a developing fetus. Women who can become pregnant must use highly effective contraception during treatment and for a period after the final dose. Men taking Sorafenib should also use effective contraception.

19. What should I do if I need to take other medications?

It is crucial to inform your oncologist of all other drugs you are taking, including over-the-counter medications and herbal supplements. Some drugs can interact with Sorafenib and affect its efficacy or increase side effects.

20. Can I get vaccinations while on Sorafenib?

You should avoid “live” vaccines. Inactivated vaccines, like some flu shots, may be safe but could be less effective. Always consult with your oncologist before receiving any type of vaccination.

21. Who is qualified to prescribe Sorafenib in the Philippines? Sorafenib is a specialty medication that must be prescribed and managed by a qualified Medical Oncologist.

22. Where can patients in the Philippines obtain Sorafenib?

Sorafenib is dispensed through major hospital pharmacies, cancer centers, or authorized specialty pharmaceutical distributors in the Philippines. It is not available at regular local drugstores.

23. How can Filipino patients get financial assistance for the high cost of Sorafenib?

The cost of Sorafenib can be a significant burden. Patients and their families in the Philippines should explore all available options:

• Inquire with the Philippine Health Insurance Corporation (PhilHealth) about coverage under the Z Benefit Package for liver cancer and other applicable benefits.
• Seek assistance from the Philippine Charity Sweepstakes Office (PCSO) and the Department of Social Welfare and Development (DSWD).
• Ask your oncologist about the manufacturer’s (Bayer) Patient Assistance Program (PAP) for Nexavar®, which may provide the drug at a subsidized cost or for free to eligible patients.

24. Are there support groups for patients in the Philippines?

Yes. Patient support groups for liver, kidney, and thyroid cancer can provide invaluable emotional and practical support. Ask your healthcare team at major cancer centers like the Philippine General Hospital (PGH) or St. Luke’s Medical Center for recommendations.

25. What is the difference between Sorafenib and other drugs like Lenvatinib?

Both are multi-kinase inhibitors used for similar types of cancer. However, they block slightly different sets of proteins and have different side effect profiles, dosing schedules, and food instructions. Your oncologist will choose the best drug for you based on your specific cancer type, overall health, and international treatment guidelines.

TRUSTED Anti Cancer  MEDICINE PROVIDER – UNNATI PHARMAX

References:-

• European Medicines Agency (EMA) – Xtandi (Enzalutamide)
  Offers the European Public Assessment Report (EPAR) with details on approval, indications, mechanism, and safety.
  https://www.ema.europa.eu/en/medicines/human/EPAR/xtandi
  European Medicines Agency (EMA)

• EMA – Enzalutamide Viatris (Generic)
  EPAR confirming the approval and bioequivalence of the generic equivalent to Xtandi.
  https://www.ema.europa.eu/en/medicines/human/EPAR/enzalutamide-viatris
  European Medicines Agency (EMA)

• EMA – Enzalutamide Product-Specific Bioequivalence Guidance
  Guidance document outlining the requirements for demonstrating bioequivalence of enzalutamide formulations (capsule/tablet).
  https://www.ema.europa.eu/en/enzalutamide-product-specific-bioequivalence-guidance