Sorafenat 200mg Tablet | Sorafenib for Liver & Kidney Cancer

Product introduction

Sorafenat Tablet belongs to the class of medicines known as tyrosine kinase inhibitors used in the treatment of liver cancer, kidney cancer, and thyroid cancer.

Sorafenat Tablet should be taken on an empty stomach, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Fatigue, nausea, loss of appetite, hair loss and diarrhea are some common side effects of this medicine. It might cause high blood pressure, so the doctor may ask you for a regular check-up of blood pressure. You must inform your doctor if you notice severe skin reaction such as skin rash, or any pain, swelling, and redness of your hands and feet.

Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or high blood pressure. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Sorafenat Tablet

Thyroid cancer
Kidney cancer
Liver cancer

Benefits of Sorafenat Tablet

In Thyroid cancer

Thyroid is a butterfly-shaped gland located at the base of your neck. Your thyroid produces hormones that regulate your heart rate, blood pressure, body temperature and weight. Thyroid cancer occurs in the cells of the thyroid and it might not cause any symptoms at first. Sorafenat Tablet restricts the oxygen supply of the cancer cells and stops its growth as well as further spread. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol or smoking while having this treatment and drink plenty of water to stay hydrated.

Side effects of Sorafenat Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Sorafenat

Fatigue
Nausea
Loss of appetite
Diarrhea
Abdominal pain
Hair loss
Weight loss
Rash
Painful blisters on hands and feet

How to use Sorafenat Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sorafenat Tablet is to be taken empty stomach.

How Sorafenat Tablet works

Sorafenat Tablet is an anti-cancer medication. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Sorafenat Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Sorafenat Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Breast feeding

UNSAFE

Sorafenat Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

SAFE

Sorafenat Tablet does not usually affect your ability to drive.

Kidney

SAFE IF PRESCRIBED

Sorafenat Tablet is safe to use in patients with kidney disease. No dose adjustment of Sorafenat Tablet is recommended.
Regular monitoring of blood tests may be advised while you are taking this medicine.

Liver

CAUTION

Sorafenat Tablet should be used with caution in patients with severe liver disease. Dose adjustment of Sorafenat Tablet may be needed. Please consult your doctor.

What if you forget to take Sorafenat Tablet?

If you miss a dose of Sorafenat Tablet, skip it and continue with your normal schedule. Do not double the dose.

Quick tips

Sorafenat Tablet is used in the treatment of liver, kidney, and thyroid cancer.
Take it without food, or with a low fat meal and a full glass of water.
Take it at the same time everyday to maintain consistent levels in your body.
Women who could get pregnant should use a reliable method of contraception to prevent pregnancy while taking this medicine.
Your doctor may regularly monitor your blood pressure while you are taking this medicine.
Inform your doctor if you get a skin rash, or any pain, swelling, and redness of your hands and feet while you are taking this medicine.
Do not change the dose or discontinue use without consulting your doctor.

FAQs

How is Sorafenat Tablet administered?

Sorafenat Tablet is an oral medicine and you should take it exactly as per your doctor’s advice. It can be taken without food or with low to moderate fat meal. It should not be taken with high-fat meal which will make Sorafenat Tablet less effective. If you are taking high-fat meal, take Sorafenib 1 hour before or two hours after high-fat meal.

For how long do I need to take Sorafenat Tablet?

If Sorafenat Tablet suits you well, then you should continue taking it for the duration suggested by the doctor. However, if you experience any side effect that bothers you, talk to your doctor immediately.

Do I need to take a treatment along with Sorafenat Tablet for it to work?

Sorafenat Tablet is used as a monotherapy, that is, it is a medicine which is used alone rather than in combination with other treatments like radiotherapy or chemotherapy.

How do I know if I am responding to Sorafenat Tablet?

While receiving treatment with Sorafenat Tablet, your doctor will most likely recommend regular scans to monitor the size of the tumor. You may also need to get regular blood tests to see if the deranged liver or kidney functions have improved or not.

What are the serious side effects that can occur while taking Sorafenat Tablet?

The possible serious side effects that may occur (not in everyone) include heart attack and heart failure, increased risk of bleeding, high blood pressure, skin problems and wound healing problems. Some other side effects which get highlighted when you go through various tests are decreased blood flow to the heart, swelling of the liver, an opening in the wall of stomach or intestines (perforation), changes in electrical activity of the heart (QT prolongation) and changes in thyroid hormone levels.

Does Sorafenat Tablet affect blood sugar levels?

Yes, Sorafenat Tablet can cause a decrease in the blood sugar levels. In fact, the levels can decrease to the extent that the patient may faint. So, it is important that the patients having diabetes check their blood sugar levels regularly. Additionally, you should also consult the doctor if the dose of anti-diabetic medicines needs to be adjusted.

I have developed redness and pain in my palms and soles ever since I started using Sorafenat Tablet. My skin is also coming off. Is this dangerous? What should I do?

It seems you have developed hand and foot skin reaction due to Sorafenat Tablet. Consult your doctor who will either interrupt your therapy for sometime or change your dose. He might also suggest some cream or lotion to treat the problem. If the problem is severe, consult a skin doctor.

TRUSTED Anti Cancer MEDICINE PROVIDER – UNNATI PHARMAX

References:-

FDA (DailyMed) — Sorafenib Tablets Fresh Prescribing Information
Comprehensive, FDA-approved prescribing details for sorafenib 200 mg tablets.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b7919013-1511-44f0-a759-3fa78a9fa178 DailyMed
FDA — ANDA Approval Letter for Mylan’s Generic Sorafenib (200 mg)
Official FDA correspondence detailing approval and 180-day exclusivity for the generic sorafenib by Mylan (Natco’s partner).
https://www.accessdata.fda.gov/drugsatfda_docs/appletter/2020/207012Orig1s000ltr.pdf FDA Access Data
PharmaAdvancement — Natco Pharma Receives USFDA Tentative Approval
Industry notice confirming that Natco Pharma (via partner Mylan) secured tentative ANDA approval for sorafenib 200 mg.
https://www.pharmaadvancement.com/drug-development/fda-approvals/natco-pharma-limited-receives-usfda-tentative-approval-for-sorafenib-tablets-200mg/ Pharma Advancement
Business Standard — Filing for FDA ANDA with Paragraph IV Certification
Reports Natco Pharma and Mylan filing an ANDA with a Paragraph IV envelope for sorafenib 200 mg, potentially earning marketing exclusivity.
https://www.business-standard.com/article/companies/natco-pharma-s-partner-mylan-files-application-for-sorafenib-with-the-usfda-115021101267_1.html Business Standard
Indian Pharma Post — Natco Launches First Generic Nexavar (Sorafenib) Tablets in U.S.
News on Natco’s launch of the first generic version of Nexavar (sorafenib) 200 mg tablets in the U.S., via partner Viatris.
https://www.indianpharmapost.com/news/natco-launches-first-generic-version-of-nexavar-tablets-in-the-us-12389

Manufacturer	Natco Pharma Ltd
Composition	Sorafenib Tosylate
Form	Tablet
Strength	200 mg
Packaging	Bottle of 120 tablets
Uses / Indications	Liver cancer (Hepatocellular carcinoma) Kidney cancer (Renal cell carcinoma) Thyroid cancer (Differentiated thyroid carcinoma)
Storage	Store in a cool, dry place below 30°C, away from sunlight

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Product introduction

Uses of Sorafenat Tablet