BEVACIZUMAB 100 & 400

Bevacizumab Injection (100mg & 400mg)

Bevacizumab is a monoclonal antibody used in the treatment of several types of cancers. It works by inhibiting angiogenesis (the growth of new blood vessels) that tumors need to grow and spread.

Description

• Generic Name: Bevacizumab

• Strengths Available: 100mg/4ml and 400mg/16ml vials

• Dosage Form: Injection for intravenous infusion

• Therapeutic Class: Antineoplastic / Monoclonal Antibody

• Indication: Used in treatment of various cancers including:

  • Colorectal cancer

  • Non-small cell lung cancer (NSCLC)

  • Renal cell carcinoma

  • Ovarian cancer

  • Glioblastoma

  • Cervical cancer

Mechanism of Action

• Bevacizumab is a VEGF (vascular endothelial growth factor) inhibitor.

• It binds to VEGF, preventing it from interacting with its receptors on endothelial cells.

• This blocks the formation of new blood vessels, thereby reducing tumor growth and metastasis.

Dosage & Administration

• Administered intravenously (IV infusion) only.

• Dosage varies depending on cancer type and patient’s condition (usually 5–15 mg/kg every 2 or 3 weeks).

• Should not be given as an IV push or bolus injection.

Side Effects

Common side effects may include:

• Hypertension

• Proteinuria (protein in urine)

• Headache

• Fatigue

• Nosebleeds

• Gastrointestinal perforation (rare but serious)

• Delayed wound healing

• Increased risk of bleeding and clotting

Precautions

• Not recommended during pregnancy (can harm fetus).

• Patients should avoid major surgery during treatment (risk of poor wound healing).

• Regular monitoring of blood pressure, urine protein, and overall health required.

Storage

• Store in a refrigerator (2°C – 8°C).

• Do not freeze or shake.

• Keep in original packaging to protect from light.

FAQs

Q1. What cancers is Bevacizumab used for?
A: Colorectal cancer, lung cancer, kidney cancer, ovarian cancer, glioblastoma, and cervical cancer.

Q2. How is it given?
A: By IV infusion in a hospital/clinic under medical supervision.

Q3. Can Bevacizumab be used alone?
A: It is usually combined with chemotherapy but may also be used as monotherapy in certain cases.

Q4. What should patients avoid during treatment?
A: Surgery, pregnancy, and activities that may increase bleeding risk.

TRUSTED Anti Cancer  MEDICINE PROVIDER – UNNATI PHARMAX

References:-

• DailyMed – Avastin (Bevacizumab) Label
  Provides comprehensive prescribing information for the injection available in 100 mg/4 mL and 400 mg/16 mL vials.
  https://fda.report/DailyMed/939b5d1f-9fb2-4499-80ef-0607aa6b114e

• DrugCentral – Bevacizumab Drug Listing
  Confirms available vial strengths (100 mg and 400 mg) for multiple branded formulations including Avastin, MVASI, and Zirabev.
  https://drugcentral.org/drugcard/4956

• EMA – Avastin (Bevacizumab) EPAR
  The European Public Assessment Report offering regulatory evaluation, included indications, mechanisms, and safety guidance for the biologic.
  https://www.ema.europa.eu/en/medicines/human/EPAR/avastin