Product introduction
Axpero 5 Tablet is an anti-cancer medicine used in the treatment of kidney cancer.
Axpero 5 Tablet can be taken with or without food, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine include high blood pressure, joint pain, and loss of appetite. Diarrhea, shortness of breath, can be serious sometimes so take medicine to treat it as prescribed by the doctor or stay hydrated. Your doctor may advise for regular blood pressure checkups while you are taking this medicine. Inform your doctor if you notice a severe headache, confusion, problems with your eyesight, nausea or vomiting.
Before taking it, tell your doctor if you have thyroid problems, liver or bleeding problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by females during treatment is important to avoid pregnancy.
Uses of Axpero Tablet
- Kidney cancer
Benefits of Axpero Tablet
In Kidney cancer
Kidney cancer occurs when abnormal cells in the kidneys grow uncontrollably, often forming a tumor that can interfere with kidney function and spread to other organs. Axpero 5 Tablet works by slowing the growth of cancer cells and reducing the blood supply to the tumor. It helps control tumor progression, relieves symptoms, and improves survival outcomes in patients with advanced kidney cancer.
Side effects of Axpero Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Axpero
- Dizziness
- Nausea
- Dry skin
- Vomiting
- Constipation
- Decreased appetite
- Muscle pain
- Anemia (low number of red blood cells)
- Headache
- Weight loss
- Weakness
- Nosebleeds
- Ringing in ear
- Diarrhea
- Voice change
- Palmar-plantar erythrodysesthesia syndrome
- Increased creatinine level in blood
- Low bicarbonate levels in blood
- Increased lipase in the blood
- Elevated levels of serum amylase
- Decreased calcium level in blood
- Upper abdominal pain
- Dehydration
- Piles
- Blood in urine
- Pulmonary embolism
- Rectal bleeding
- Breathlessness
- Fatigue
- High blood pressure
How to use Axpero Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Axpero 5 Tablet may be taken with or without food, but it is better to take it at a fixed time.
How Axpero Tablet works
Axpero 5 Tablet is an anti-cancer medication. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.
Safety advice
Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Axpero 5 Tablet. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Axpero 5 Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Axpero 5 Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
UNSAFE
Axpero 5 Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
SAFE IF PRESCRIBED
Axpero 5 Tablet is safe to use in patients with kidney disease. No dose adjustment of Axpero 5 Tablet is recommended.
Liver
CAUTION
Axpero 5 Tablet should be used with caution in patients with liver disease. Dose adjustment of Axpero 5 Tablet may be needed. Please consult your doctor.
Limited information is available on the use of Axpero 5 Tablet in patients with the severe liver disease.
Limited information is available on the use of Axpero 5 Tablet in patients with the severe liver disease.
What if you forget to take Axpero Tablet?
If you miss a dose of Axpero 5 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick tips
- Take it with or without food, preferably at the same time each day.
- Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if it doesn’t stop or if you find blood in your stools.
- Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine and for a month after you stop taking it.
- Monitor your blood pressure regularly while taking this medication. Inform your doctor if you notice symptoms of very high blood pressure such as severe headache, confusion, problems with your eyesight, nausea or vomiting.
- It may cause serious bleeding problem. Inform your doctor if you get headaches, stomach pain or if you notice blood in your urine or stools.
- Do not take this medicine if you are pregnant, planning to conceive or breastfeeding.
- Take it with or without food, preferably at the same time each day.
- Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if it doesn’t stop or if you find blood in your stools.
- Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine and for a month after you stop taking it.
- Monitor your blood pressure regularly while taking this medication. Inform your doctor if you notice symptoms of very high blood pressure such as severe headache, confusion, problems with your eyesight, nausea or vomiting.
- It may cause serious bleeding problem. Inform your doctor if you get headaches, stomach pain or if you notice blood in your urine or stools.
- Do not take this medicine if you are pregnant, planning to conceive or breastfeeding.
FAQs
What are the possible signs and symptoms of kidney cancer?
Some possible signs and symptoms of kidney cancer include blood in the urine (hematuria) which may appear dark red, orange, or pink. As kidney cancer progresses, it may produce other symptoms such as persistent pain, pressure just below the ribs, or intense fatigue.
How long should I take the Axpero 5 Tablet?
The duration of treatment varies from person to person. Your doctor will decide treatment duration based on your condition, response to treatment, and tolerance to side effects. Your doctor may decrease your dose or stop your treatment temporarily or permanently if you experience side effects.
When should I call my doctor right away?
Get medical help right away if you have signs of allergic reaction such as rash, hives, itching, and blisters. Also, let your doctor know if you notice bleeding or blood in your cough, very high blood pressure, signs of thyroid problems such as a change in weight, nervousness, restlessness, weakness, thinning of hair after taking Axpero 5 Tablet. Also, if you feel sudden mood changes, fast heart rate, change in voice, fever, or chills, visit your doctor without delay.
What lab tests are important before starting Axpero 5 Tablet?
Your doctor may advise you to undergo lab or medical tests such as blood pressure, thyroid function, kidney function, liver or pancreatic function tests, complete blood counts, urine tests, blood mineral levels including sodium or potassium before starting this medication. Women of childbearing age should have a pregnancy test before starting this medicine.
Who should not take the Axpero 5 Tablet?
People who are allergic to axitinib or any other ingredient of this medicine should not take Axpero 5 Tablet. Talk to your doctor if you are not sure.
Does Axpero 5 Tablet affect fertility?
Yes, this medicine may cause fertility issues in males as well as females. Talk to your doctor before starting your treatment to know about ways to preserve fertility.
I feel exhausted after starting treatment with Axpero 5 Tablet. What should I do?
General tiredness/fatigue is a common side effect experienced during treatment with Axpero 5 Tablet. You may need to adjust your schedule to manage fatigue. Take ample amounts of rest and do not indulge in physically exhausting activities. Exercise, such as walking, can help cope up with fatigue.
How do I know if I have developed thyroid problems after taking Axpero 5 Tablet?
Regular monitoring of thyroid function is recommended before as well as during your treatment with Axpero 5 Tablet. Your doctor will advise blood tests to assess the same. Tell your doctor if you have symptoms such as feeling more tired than usual, weight gain or loss, sensitivity to hot or cold weather, hair loss, voice changes (such as deepening of the voice), muscle cramps, and aches.
What is Reversible Posterior Leukoencephalopathy Syndrome?
Reversible Posterior Leukoencephalopathy Syndrome (RPLS) is a rare but serious neurological complication associated with the use of Axpero 5 Tablet. It is characterized by symptoms such as headaches, vision problems, mental changes, seizures, high blood pressure, weakness, and swelling in the brain. This condition is reversible and symptoms subsides once treated. Consult your doctor right away if you experience any of these worrisome episodes while taking Inlyta tablets.
I have swelling in my ankles and feet after I started taking Axpero 5 Tablets? What does this mean?
This medicine may cause side effects such as excessive tiredness, swelling of the abdomen, legs, or ankles, shortness of breath, or protruding neck veins. These are alarming and indicate chances of developing heart failure. The use of Axpero 5 Tablet is associated with an increased risk of heart failure events and these symptoms must therefore be taken seriously and addressed at the earliest. Tell your doctor without any delay if you notice any of these episodes.
How can I store Axpero 5 Tablet at home?
Store the medicine at room temperature at a dry place beyond the reach of the children and pets to avoid any accidental intake.
References:-
- Philippines Food and Drug Administration (FDA) – Drug Registration (Specific Product):
- https://verification.fda.gov.ph/ALL_DrugProductslist.php/ALL_DrugProductsview.php?showdetail=®istration_number=DR-XY45687
- (Registration entry for Lenvima 10mg Capsule in the Philippines FDA portal, confirming local approval and generic name.)
- U.S. Food and Drug Administration (FDA) – Approval Summary (for HCC Indication):
- https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-lenvatinib-unresectable-hepatocellular-carcinoma
- (FDA approval summary based on the REFLECT trial for unresectable Hepatocellular Carcinoma (HCC).)
- NIH – PubMed Central (PMC) – Review on HCC Efficacy (REFLECT Trial):
- https://pmc.ncbi.nlm.nih.gov/articles/PMC11816230/
- (Real-world long-term survival study of Lenvatinib in Hepatocellular Carcinoma (HCC), comparing results to the pivotal REFLECT trial.)
- NIH – PubMed Central (PMC) – Dose & Safety in Multiple Cancers:
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9484451/
- (A PMC review article discussing Lenvatinib dose, efficacy, and safety across multiple malignancies, including recommended dose adjustments.)
- European Medicines Agency (EMA) – Product Information:
- https://www.ema.europa.eu/en/medicines/human/EPAR/lenvima
- (EPAR Summary for Lenvima, detailing indications for DTC, HCC, RCC, and Endometrial Carcinoma, and its mechanism as a TKI.)
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