Product introduction
Axishil 1mg Tablet is an anti-cancer medicine used in the treatment of kidney cancer.
Axishil 1mg Tablet can be taken with or without food, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine include high blood pressure, joint pain, and loss of appetite. Diarrhea, shortness of breath, can be serious sometimes so take medicine to treat it as prescribed by the doctor or stay hydrated. Your doctor may advise for regular blood pressure checkups while you are taking this medicine. Inform your doctor if you notice a severe headache, confusion, problems with your eyesight, nausea or vomiting.
Before taking it, tell your doctor if you have thyroid problems, liver or bleeding problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by females during treatment is important to avoid pregnancy.
Uses of Axishil Tablet
- Kidney cancer
Benefits of Axishil Tablet
In Kidney cancer
Kidney cancer occurs when abnormal cells in the kidneys grow uncontrollably, often forming a tumor that can interfere with kidney function and spread to other organs. Axishil 1mg Tablet works by slowing the growth of cancer cells and reducing the blood supply to the tumor. It helps control tumor progression, relieves symptoms, and improves survival outcomes in patients with advanced kidney cancer.
Side effects of Axishil Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Axishil
- Dizziness
- Nausea
- Dry skin
- Vomiting
- Constipation
- Decreased appetite
- Muscle pain
- Anemia (low number of red blood cells)
- Headache
- Weight loss
- Weakness
- Nosebleeds
- Ringing in ear
- Diarrhea
- Voice change
- Palmar-plantar erythrodysesthesia syndrome
- Increased creatinine level in blood
- Low bicarbonate levels in blood
- Increased lipase in the blood
- Elevated levels of serum amylase
- Decreased calcium level in blood
- Upper abdominal pain
- Dehydration
- Piles
- Blood in urine
- Pulmonary embolism
- Rectal bleeding
- Breathlessness
- Fatigue
- High blood pressure
How to use Axishil Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Axishil 1mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
How Axishil Tablet works
Axishil 1mg Tablet is an anti-cancer medication. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.
Safety advice
Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Axishil 1mg Tablet. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Axishil 1mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Axishil 1mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
UNSAFE
Axishil 1mg Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
SAFE IF PRESCRIBED
Axishil 1mg Tablet is safe to use in patients with kidney disease. No dose adjustment of Axishil 1mg Tablet is recommended.
Liver
CAUTION
Axishil 1mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Axishil 1mg Tablet may be needed. Please consult your doctor.
Limited information is available on the use of Axishil 1mg Tablet in patients with the severe liver disease.
Limited information is available on the use of Axishil 1mg Tablet in patients with the severe liver disease.
What if you forget to take Axishil Tablet?
If you miss a dose of Axishil 1mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick tips
- Take it with or without food, preferably at the same time each day.
- Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if it doesn’t stop or if you find blood in your stools.
- Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine and for a month after you stop taking it.
- Monitor your blood pressure regularly while taking this medication. Inform your doctor if you notice symptoms of very high blood pressure such as severe headache, confusion, problems with your eyesight, nausea or vomiting.
- It may cause serious bleeding problem. Inform your doctor if you get headaches, stomach pain or if you notice blood in your urine or stools.
- Do not take this medicine if you are pregnant, planning to conceive or breastfeeding.
- Take it with or without food, preferably at the same time each day.
- Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if it doesn’t stop or if you find blood in your stools.
- Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine and for a month after you stop taking it.
- Monitor your blood pressure regularly while taking this medication. Inform your doctor if you notice symptoms of very high blood pressure such as severe headache, confusion, problems with your eyesight, nausea or vomiting.
- It may cause serious bleeding problem. Inform your doctor if you get headaches, stomach pain or if you notice blood in your urine or stools.
- Do not take this medicine if you are pregnant, planning to conceive or breastfeeding.
FAQs
What are the possible signs and symptoms of kidney cancer?
Some possible signs and symptoms of kidney cancer include blood in the urine (hematuria) which may appear dark red, orange, or pink. As kidney cancer progresses, it may produce other symptoms such as persistent pain, pressure just below the ribs, or intense fatigue.
How long should I take the Axishil 1mg Tablet?
The duration of treatment varies from person to person. Your doctor will decide treatment duration based on your condition, response to treatment, and tolerance to side effects. Your doctor may decrease your dose or stop your treatment temporarily or permanently if you experience side effects.
When should I call my doctor right away?
Get medical help right away if you have signs of allergic reaction such as rash, hives, itching, and blisters. Also, let your doctor know if you notice bleeding or blood in your cough, very high blood pressure, signs of thyroid problems such as a change in weight, nervousness, restlessness, weakness, thinning of hair after taking Axishil 1mg Tablet. Also, if you feel sudden mood changes, fast heart rate, change in voice, fever, or chills, visit your doctor without delay.
What lab tests are important before starting Axishil 1mg Tablet?
Your doctor may advise you to undergo lab or medical tests such as blood pressure, thyroid function, kidney function, liver or pancreatic function tests, complete blood counts, urine tests, blood mineral levels including sodium or potassium before starting this medication. Women of childbearing age should have a pregnancy test before starting this medicine.
Who should not take the Axishil 1mg Tablet?
People who are allergic to axitinib or any other ingredient of this medicine should not take Axishil 1mg Tablet. Talk to your doctor if you are not sure.
Does Axishil 1mg Tablet affect fertility?
Yes, this medicine may cause fertility issues in males as well as females. Talk to your doctor before starting your treatment to know about ways to preserve fertility.
I feel exhausted after starting treatment with Axishil 1mg Tablet. What should I do?
General tiredness/fatigue is a common side effect experienced during treatment with Axishil 1mg Tablet. You may need to adjust your schedule to manage fatigue. Take ample amounts of rest and do not indulge in physically exhausting activities. Exercise, such as walking, can help cope up with fatigue.
How do I know if I have developed thyroid problems after taking Axishil 1mg Tablet?
Regular monitoring of thyroid function is recommended before as well as during your treatment with Axishil 1mg Tablet. Your doctor will advise blood tests to assess the same. Tell your doctor if you have symptoms such as feeling more tired than usual, weight gain or loss, sensitivity to hot or cold weather, hair loss, voice changes (such as deepening of the voice), muscle cramps, and aches.
What is Reversible Posterior Leukoencephalopathy Syndrome?
Reversible Posterior Leukoencephalopathy Syndrome (RPLS) is a rare but serious neurological complication associated with the use of Axishil 1mg Tablet. It is characterized by symptoms such as headaches, vision problems, mental changes, seizures, high blood pressure, weakness, and swelling in the brain. This condition is reversible and symptoms subsides once treated. Consult your doctor right away if you experience any of these worrisome episodes while taking Inlyta tablets.
I have swelling in my ankles and feet after I started taking Axishil 1mg Tablets? What does this mean?
This medicine may cause side effects such as excessive tiredness, swelling of the abdomen, legs, or ankles, shortness of breath, or protruding neck veins. These are alarming and indicate chances of developing heart failure. The use of Axishil 1mg Tablet is associated with an increased risk of heart failure events and these symptoms must therefore be taken seriously and addressed at the earliest. Tell your doctor without any delay if you notice any of these episodes.
How can I store Axishil 1mg Tablet at home?
Store the medicine at room temperature at a dry place beyond the reach of the children and pets to avoid any accidental intake.
References:-
- Philippines Food and Drug Administration (FDA) – Drug Registration (Specific Product):
- https://verification.fda.gov.ph/drug_productsview.php?showdetail=®istration_number=DR-XY43765
- (Registration entry for Inlyta 1mg Tablet (Axitinib) in the Philippines FDA portal, confirming local approval and generic name.)
- U.S. Food and Drug Administration (FDA) – Drug Label (Inlyta/Axitinib):
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/202324lbl.pdf
- (The original FDA label for Axitinib, listing the 1mg tablet and the dose modification guidelines, which allow reduction or slow escalation.)
- NIH – PubMed Central (PMC) – Combination Therapy Survival Data:
- https://theoncologypharmacist.com/issues/2019/may-2019-vol-12-no-2/first-line-pembrolizumab-plus-axitinib-combination-boosts-survival-in-metastatic-renal-cell-carcinoma
- (Trial results reviewing the significant improvement in Overall Survival (OS) when Axitinib is combined with Pembrolizumab as first-line therapy.)
- NIH – PubMed Central (PMC) – Review on PK/PD and Dose Titration:
- https://pmc.ncbi.nlm.nih.gov/articles/PMC4175417/
- (Pharmacokinetic/Pharmacodynamic (PK/PD) analysis of Axitinib in metastatic RCC, supporting the concept of dose titration (which utilizes the lower strength 1mg tablet) to maximize exposure and efficacy.)
- ResearchGate – Review on Axitinib’s Role in RCC:
- https://www.researchgate.net/publication/299495734_Axitinib_in_the_treatment_of_renal_cell_carcinoma_patient_selection_and_perspectives
- (Review summarizing Axitinib’s well-established role in mRCC after prior therapy, discussing the clinical, toxicity, and dosing considerations.)
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