Abiione 250mg Abiraterone Acetate (Zytiga) for Prostate Cancer

Product Introduction

Xbira 500 Tablet is an oral anticancer medication for the management of prostate cancer. Containing Abiraterone Acetate as its active ingredient, it is a potent inhibitor of androgen biosynthesis. This medication is designed to significantly reduce the production of male hormones, which are known to fuel the growth of prostate cancer cells. Xbira 500 Tablet is an essential part of treatment regimens for advanced prostate cancer.

Uses of Xbira 500 Tablet Xbira 500 Tablet is indicated for the treatment of:

• Metastatic Castration-Resistant Prostate Cancer (mCRPC): In adult men, it is used in combination with prednisone or prednisolone to treat prostate cancer that has metastasized and is no longer responding to standard hormonal treatments.
• Metastatic High-Risk Castration-Sensitive Prostate Cancer (mHSPC): Used in conjunction with androgen deprivation therapy (ADT) and a corticosteroid, it is also indicated for newly diagnosed men with high-risk, metastatic prostate cancer.

Benefits of Xbira 500 Tablet The use of Xbira 500 Tablet provides significant advantages in prostate cancer treatment:

• Targeted Mechanism: It specifically and irreversibly inhibits the enzyme CYP17, which is a key regulator in the production of androgens. This targeted action starves cancer cells of the hormones they need to proliferate.
• Disease Progression Control: By effectively lowering androgen levels, Xbira 500 Tablet helps to slow the growth and spread of the cancer, thereby improving patient outcomes and overall survival rates.
• Reduced Side Effects: When taken with a low-dose corticosteroid, the incidence and severity of certain side effects like hypertension and fluid retention are reduced, making the treatment more manageable for the patient.

Side Effects of Xbira 500 Tablet While Xbira 500 Tablet is a vital medication, it is associated with potential side effects.

• Common Side Effects: Fluid retention (edema), high blood pressure (hypertension), hypokalemia (low blood potassium), fatigue, joint swelling, diarrhea, and hot flashes.
• Serious Side Effects (less common): Severe liver toxicity (symptoms include yellowing of the skin/eyes, dark urine), adrenal insufficiency, and cardiac issues (such as irregular heartbeat or heart failure).

Disclaimer: This is not a complete list. Patients should be advised to consult a healthcare professional for a full review of potential side effects and their management.

How to Use Xbira 500 Tablet

• Dosage: The recommended dose is 1,000 mg of Abiraterone Acetate (two 500mg tablets) taken orally once daily. This should be combined with a prescribed dose of a corticosteroid, typically prednisone or prednisolone.
• Administration: Tablets must be swallowed whole with water and should not be crushed, chewed, or broken. It is critical to take Xbira on an empty stomach—at least one hour before eating or at least two hours after a meal. This ensures optimal absorption and effectiveness, as food significantly increases the drug’s absorption and can lead to higher exposure and increased side effects.
• Consistency: For best results, patients should take the medication at the same time each day.

How Xbira 500 Tablet Works Xbira 500 Tablet, containing Abiraterone Acetate, functions as a powerful inhibitor of the enzyme 17α-hydroxylase/C17,20-lyase (CYP17). This enzyme is a critical catalyst in the androgen biosynthesis pathway, which occurs in the testes, adrenal glands, and within the prostate tumor itself. By blocking CYP17, Abiraterone Acetate drastically reduces the synthesis of androgens, including testosterone. This action deprives prostate cancer cells of the hormonal “fuel” they require to grow, multiply, and spread, effectively slowing down the disease’s progression.

Safety Advice

• Monitoring: Patients should undergo regular monitoring of blood pressure, liver function, and serum potassium levels.
• Cardiovascular & Hepatic Health: Extreme caution and close monitoring are necessary for patients with a history of cardiovascular disease or liver impairment.
• Pregnancy & Contraception: Xbira 500 Tablet is for use in male patients only. It is contraindicated in women, particularly those who are pregnant or may become pregnant, as it can cause harm to a fetus. Men with a partner of childbearing potential must use effective contraception during and for a period after treatment. Women should not handle these tablets without gloves.
• Drug Interactions: Inform your physician about all medications, including over-the-counter and herbal supplements, to avoid potential drug interactions. Avoid combining Xbira with other drugs that may affect liver function or electrolyte balance.

What if You Forget to Take Xbira 500 Tablet? If a dose is missed, the patient should skip that dose and continue with their regular schedule the next day. A double dose should never be taken to compensate for a missed one, as this can increase the risk of side effects.

Quick Tips

• Always take Xbira 500 Tablet on an empty stomach.
• Use a consistent time each day to take the medication.
• Never stop treatment without consulting a healthcare professional.
• Store the tablets in their original container in a cool, dry place.

FAQs

Q1: What is the primary market for Xbira 500 Tablet for bulk buyers? A: Xbira 500 Tablet is a high-value oncology product with a strong market presence in the treatment of prostate cancer. Bulk buyers in our target countries—Australia, Germany, Singapore, the UK, the US, and the Philippines—will find strong demand from specialized hospitals, oncology centers, and pharmaceutical distribution networks.

Q2: How does Xbira 500 Tablet differ from traditional chemotherapy agents? A: Xbira 500 Tablet is not a traditional chemotherapy drug. It is a hormonal therapy that works by inhibiting a specific enzyme to block the production of male hormones that cancer cells rely on. This is a targeted approach that is distinct from the cytotoxic action of conventional chemotherapy.

Q3: What are the storage and handling requirements for Xbira 500 Tablet for bulk shipping? A: Xbira 500 Tablet should be stored at room temperature (below 30°C) and protected from moisture and light. Our bulk shipments are packaged to ensure these conditions are maintained during transit, and we provide all necessary documentation for compliance with international pharmaceutical shipping regulations.

Q4: Is the 500mg tablet a replacement for the 250mg version? A: The 500mg tablet is a higher-strength option designed for patient convenience, as the typical daily dose is 1,000 mg (two 500mg tablets instead of four 250mg tablets). Both strengths contain the same active ingredient and are equally effective when taken as prescribed. The choice between strengths often depends on local market preferences and patient convenience.

Q5: What safety information is most critical for suppliers to emphasize to their clients? A: Suppliers should highlight the critical “empty stomach” rule for administration, the necessity of concurrent use with a corticosteroid, and the importance of patient monitoring for potential side effects such as elevated blood pressure, low potassium levels, and liver issues. It is also crucial to emphasize that the drug is for male patients only and that pregnant women should not handle the tablets.

Q6: Does UnnatiPharmax provide a Certificate of Analysis (CoA) for bulk orders? A: Yes, every bulk order of Xbira 500 Tablet is shipped with a comprehensive Certificate of Analysis (CoA) to verify its quality, purity, and adherence to specified pharmaceutical standards. This ensures transparency and compliance with regulatory requirements in all destination countries.

References:-

• U.S. Food and Drug Administration (FDA)
  • Abiraterone Acetate (Zytiga) drug label: https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/202379lbl.pdf
• European Medicines Agency (EMA)
  • Zytiga (brand name Abiraterone Acetate) EPAR: https://www.ema.europa.eu/en/medicines/human/EPAR/zytiga
• National Institutes of Health (NIH)
  • National Cancer Institute (NCI) definition: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/abiraterone-acetate
  • PubMed Central (PMC) – Example research paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018245/
• ClinicalTrials.gov
  • Example clinical trial for Abiraterone Acetate: https://clinicaltrials.gov/study/NCT00887198