Product introduction

Lenalid 15 Capsule belongs to a group of medicines that affect how your immune system works. $It is used in the treatment of multiple myeloma and myelodysplastic syndrome.

Lenalid 15 Capsule can be taken with or without food, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Some common side effects of this medicine include headache, weakness, nausea, rash, and dizziness amongst others. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections or bleeding. Hence, take caution while performing the activity that might increase your chances of bleeding or avoid contact with people suffering from an infection such as a cold. Regular blood tests are required to check your blood cells while on treatment.

Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. You are advised to drink plenty of fluids to stay hydrated while taking this medicine.

Uses of Lenalid Capsule

Multiple myeloma
Treatment of Myelodysplastic syndrome

Benefits of Lenalid Capsule

In Treatment of Myelodysplastic syndrome

Myelodysplastic Syndromes (MDS) are a group of rare blood disorders characterized by abnormal development of blood cells in the bone marrow. In MDS, the bone marrow fails to produce enough healthy and fully matured blood cells, leading to low blood cell counts, which can result in anemia, infections, and bleeding problems.

Lenalid 15 Capsule is used to treat certain types of MDS, specifically those associated with a specific part of the chromosomes in the blood cells. It works by helping the immune system make more healthy blood cells in the bone marrow. Lenalid 15 Capsule helps improve the production of red blood cells, reducing the need for frequent blood transfusions and making them feel better. It is important to check-up and monitor regularly to make sure it is safe and effective.

Side effects of Lenalid Capsule

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Lenalid

Headache
Nausea
Rash
Breathlessness
Dizziness
Fatigue
Decreased white blood cell count (neutrophils)
Joint pain
Itching
Diarrhea
Low blood platelets
Peripheral edema
Cough
Back pain
Upper respiratory tract infection
Decreased appetite
Nasopharyngitis (inflammation of the throat and nasal passages)

How to use Lenalid Capsule

Take this medicine in the dose and duration as advised by your doctor. Lenalid 15 Capsule may be taken with or without food, but it is better to take it at a fixed time.

How Lenalid Capsule works

Lenalid 15 Capsule is an anti-cancer medication. It works by enhancing the immune system that indirectly attacks the cancer cells. It prevents the growth of new blood vessels within the tumor. It also restricts the production of chemical messengers (cytokine and growth factor) which are responsible for the growth of cancer cells. This is how it works against cancer.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Lenalid 15 Capsule. Please consult your doctor.

Pregnancy

UNSAFE

Lenalid 15 Capsule is highly unsafe to use during pregnancy. Seek your doctor’s advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

Breast feeding

CONSULT YOUR DOCTOR

Lenalid 15 Capsule is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

UNSAFE

Lenalid 15 Capsule may cause side effects which could affect your ability to drive.
You may feel dizzy, tired, sleepy, have vertigo or blurred vision after taking Lenalid 15 Capsule and this may affect your ability to drive.

Kidney

CAUTION

Lenalid 15 Capsule should be used with caution in patients with kidney disease. Dose adjustment of Lenalid 15 Capsule may be needed. Please consult your doctor.

Liver

CAUTION

Lenalid 15 Capsule should be used with caution in patients with liver disease. Dose adjustment of Lenalid 15 Capsule may be needed. Please consult your doctor.

What if you forget to take Lenalid Capsule?

If you miss a dose of Lenalid 15 Capsule, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Quick tips

You may be monitored with regular blood tests before and during the treatment as lenalidomide may cause a fall in the white blood cells and platelets, required to fight infection, Hemoglobin and blood clotting.
Avoid activities that may cause bruising or injury and avoid contact with people who have colds or infections.
It makes your skin sensitive towards sunlight. Apply sunscreen or wear protective while going out.
It may cause dehydration. Drink plenty of water to stay hydrated while taking medication.
It is not recommended for use in children and adolescents under 18 years.
You should use proper contraceptive methods at least 4 weeks before, during and until 4 weeks after stopping treatment.
Woman of childbearing potential will be required to undergo pregnancy tests before and after the treatment.
You should inform your doctor or dentist that you are taking Lenalid 15 Capsule before you receive any medical or dental care, emergency care, or surgery.
It may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
You may be at risk of developing acute myelogenous leukemia, fatal liver problems, severe skin reactions, and fatal heart problems during treatment with Lenalid 15 Capsule. You should discuss in advance the benefits and risks of taking this medicine.

FAQs

Can I take Lenalid 15 Capsule empty stomach?

Lenalid 15 Capsule may be taken with or without food. Always take it exactly as prescribed by your doctor. Do not crush, cut or chew the capsules. Swallow it whole with water. You should take Lenalid 15 Capsule at about the same time on the scheduled days.

Can Lenalid 15 Capsule be given to patients who are on dialysis?

Yes, Lenalid 15 Capsule is given to dialysis patients after the dialysis is done. However, the doctor may adjust the dose if needed in patients undergoing.

What are the side effects of Lenalid 15 Capsule?

Lenalid 15 Capsule may cause side effects which include diarrhea, constipation, stomach pain, loss of appetite, weight loss, weakness, dizziness, change in ability to taste, and pain or burning of the tongue, mouth, or throat. The medicine may also cause decreased sense of touch, burning or tingling in the hands or feet, difficulty falling asleep or staying asleep, depression, and joint, muscle, bone, or back pain. You may also experience sweating, dry skin, abnormal hair growth in women, uncontrollable shaking of a part of the body, decrease in sexual desire or ability or painful, frequent, or urgent urination. Tell your doctor if any of these symptoms are severe or do not go away.

Can Lenalid 15 Capsule cause cancer?

People with multiple myeloma (a form of cancer that begins in plasma cells, a type of white blood cell) who receive melphalan (chemotherapy) and a blood stem cell transplant with the addition of Lenalid 15 Capsule have a higher risk of developing new cancers. These types of cancers may include certain blood cancers (acute myelogenous leukemia or AML) and a type of lymphoma called Hodgkin lymphoma. Talk to your doctor about your risk of developing new cancers if you are taking Lenalid 15 Capsule.

Do I need to get any blood tests done while on Lenalid 15 Capsule?

Your doctor will ask you to have a blood test before treatment and every week for the first 8 weeks of treatment. You may need to continue taking the blood tests at least every month after treatment with Lenalid 15 Capsule ends. Frequent blood tests are important as Lenalid 15 Capsule may decrease the blood cells that help fight infection (white blood cells) and help the blood to clot (platelets).

Do I need to use birth control methods while using Lenalid 15 Capsule?

Women who can become pregnant must use two acceptable forms of birth control for 4 weeks before they begin taking Lenalid 15 Capsule. Continue using contraceptives during your treatment, including the times when your doctor tells you to temporarily stop taking Lenalid 15 Capsule, and for 4 weeks after your final dose. In men, Lenalid 15 Capsule may pass into the semen while they are on treatment. Therefore, men must always use a latex condom every time they have sexual contact, even if they have had a vasectomy (surgery that prevents a man from causing a pregnancy). Use the contraceptive while you are taking Lenalid 15 Capsule, during any breaks in your treatment, and for 4 weeks after your final dose.

References:-

Philippines Food and Drug Administration (FDA) – Drug Registration (Specific Product):
- https://verification.fda.gov.ph/drug_productsview.php?showdetail=&registration_number=DR-XY48492
- (Registration entry for Lenzest 25 (Lenalidomide 25mg Capsule) in the Philippines FDA portal, confirming local approval and generic name.)
U.S. Food and Drug Administration (FDA) – Drug Label (Revlimid/Lenalidomide):
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021880s049lbl.pdf
- (Full Prescribing Information for Lenalidomide, including the 25mg dosage)
NIH – PubMed Central (PMC) – Review on Multiple Myeloma:
- https://pmc.ncbi.nlm.nih.gov/articles/PMC3430086/
- (Lenalidomide for the treatment of relapsed and refractory multiple myeloma)
NIH – PubMed Central (PMC) – Practice Guideline/Survival:
- https://pmc.ncbi.nlm.nih.gov/articles/PMC5013840/
- (FDA Approval Summary and Review of Lenalidomide as First-Line Therapy for Multiple Myeloma)
International Myeloma Foundation (IMF) – Drug Information:
- https://www.myeloma.org/revlimid-lenalidomide
- (Authoritative non-commercial information on Lenalidomide dosing and side effect management)

Brand Name	Lenalid 15 Capsule
Generic Name	Lenalidomide
Strength	15 mg
Drug Class	Immunomodulatory Agent (IMiD) / Anti-neoplastic
Therapeutic Class	Anti-cancer / Treatment for Hematologic Malignancies
Mechanism of Action	Lenalid (Lenalidomide) is an immunomodulator that works by: 1) Enhancing the immune system's attack on cancer cells (T-cell and NK-cell activation). 2) Inhibiting angiogenesis (new blood vessel growth to tumors). 3) Directly suppressing the growth and promoting the programmed cell death (apoptosis) of malignant blood cells.
Indications (Uses)	Used in adults for the treatment of: Multiple Myeloma (MM) (in combination with Dexamethasone or as maintenance therapy), Myelodysplastic Syndromes (MDS) (specifically for transfusion-dependent anemia due to a specific chromosome deletion, $\text{del}(5\text{q})$), Mantle Cell Lymphoma (MCL), and Follicular Lymphoma (FL).
Dosage & Administration	Recommended Dose: The dose is highly variable, prescribed based on disease and renal function ($\text{CrCl}$). Typical starting doses are 15 mg or 25 mg once daily (for MM/MCL combination therapy) or 10 mg once daily (for MDS), often administered cyclically. How to Take: Swallow capsule whole. Do not open, crush, or chew. Can be taken with or without food, but at the same time each day.

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Product introduction

Uses of Lenalid Capsule