🔬 What is Imatinib?
Imatinib Mesylate is a tyrosine kinase inhibitor (TKI) used to treat cancers that are caused by specific mutations. It is especially effective in:
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Chronic Myeloid Leukemia (CML) – all stages
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Acute Lymphoblastic Leukemia (ALL) – Philadelphia chromosome-positive
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Gastrointestinal Stromal Tumors (GIST) – advanced/metastatic
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Hypereosinophilic Syndrome (HES) and Systemic Mastocytosis
Imatinib works at the genetic level by blocking the BCR-ABL protein that causes uncontrolled cancer cell growth.
💊 Available Strengths:
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Imatinib 100mg Tablets
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Imatinib 400mg Tablets
Manufactured by top brands such as Natco (Veenat), Cipla (Imatib), Dr. Reddy’s (Imanib), and Novartis (Glivec).
✅ Key Benefits:
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Specifically targets cancer cells while sparing healthy tissue
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Proven to increase survival and remission rates in leukemia and GIST
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Oral administration for home-based treatment
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Suitable for long-term cancer management
🧬 How Imatinib Works:
Imatinib blocks the abnormal protein BCR-ABL tyrosine kinase, which is produced by a mutated gene in leukemia and GIST patients. This stops the multiplication of cancerous white blood cells and tumor cells, leading to remission or disease stabilization.
🛒 Why Buy From Unnatipharmax?
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Competitive pricing on FDA-approved generics
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Cold-chain secured packaging for quality assurance
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24/7 patient care support with secure shipping globally
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Trusted by oncologists and cancer hospitals worldwide
📦 Packaging & Dosage:
| Strength | Pack Size | Common Brand Names |
|---|---|---|
| 100mg | 10 / 60 / 120 tablets | Imatib, Veenat, Imanib, Glivec |
| 400mg | 10 / 30 / 90 tablets | Imatib 400, Veenat 400 |
Take once or twice daily as prescribed. Can be taken with food and a full glass of water.
⚠️ Precautions:
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Use under strict oncologist supervision
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Common side effects: nausea, cramps, fatigue, fluid retention
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Monitor blood counts and liver function during treatment
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Not to be used in pregnancy
🧴 Storage Instructions:
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Store at 15°C – 30°C
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Protect from moisture and sunlight
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Keep away from children
Frequently Asked Questions (FAQ) for Imatinib Tablets (100mg / 400mg)
Understanding Imatinib and Its Use
1. What is Imatinib and what is it used for?
Imatinib is a life-changing oral targeted therapy drug. It is primarily used to treat specific types of cancer, most notably:
- Chronic Myeloid Leukemia (CML) that is Philadelphia chromosome-positive (Ph+).
- Gastrointestinal Stromal Tumors (GIST) that are KIT (CD117)-positive.
- Certain types of Acute Lymphoblastic Leukemia (ALL) that are Ph+.
2. How does Imatinib work against cancers like CML and GIST?
Imatinib is a tyrosine kinase inhibitor (TKI). It works by precisely targeting and blocking the specific abnormal proteins (like Bcr-Abl in CML and c-KIT in GIST) that signal cancer cells to grow and multiply uncontrollably. By blocking these signals, it stops the cancer’s growth.
3. Is Imatinib a type of traditional chemotherapy?
No, Imatinib is a targeted therapy. Unlike traditional chemotherapy, which affects all rapidly dividing cells, Imatinib is designed to attack specific molecular targets found on cancer cells, resulting in a different and often more manageable side effect profile.
4. What are the common brand names for Imatinib in the Philippines?
The original innovator brand is Gleevec® (also known as Glivec® in many regions), manufactured by Novartis. Due to its importance and patent status, several high-quality generic versions are also registered and available in the Philippines, which your oncologist may prescribe.
Treatment and Dosing
5. How should Imatinib tablets be taken?
Imatinib should be taken with a meal and a large glass of water. This helps to minimize stomach irritation, a common side effect.
6. Why does Imatinib come in 100mg and 400mg tablet strengths?
The different strengths allow your oncologist to prescribe the exact daily dose you need (e.g., 400mg, 600mg, 800mg) by combining the tablets in various ways, without needing to cut or split them.
7. What is the typical starting dose for CML or GIST?
The typical starting dose for chronic phase CML is 400mg once daily, and for GIST, it is also 400mg once daily. However, your oncologist will determine the exact starting dose based on your specific condition and health status.
8. What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. However, if it’s almost time for your next dose, skip the missed dose and return to your regular schedule. Do not take a double dose to make up for the missed one.
9. How long will I need to take Imatinib?
For conditions like CML, Imatinib is typically a lifelong treatment. It effectively manages the disease and keeps it in remission, but stopping the medication can cause the leukemia to return. You must not stop taking it unless specifically instructed by your oncologist.
Side Effects and Management
10. What are the most common side effects of Imatinib?
Common side effects include fluid retention (edema), especially around the eyes and in the ankles; muscle cramps; nausea or stomach upset; diarrhea; skin rash; and fatigue.
11. Why does Imatinib cause swelling or fluid retention (edema)?
Fluid retention is one of the most common side effects. The exact mechanism is complex, but it’s a known effect of the drug. Your doctor will monitor your weight and check for swelling. Limiting salt intake can help manage this.
12. How can I manage the muscle cramps caused by Imatinib?
Staying well-hydrated by drinking plenty of water is key. Gentle stretching and ensuring adequate intake of minerals like calcium, magnesium, and potassium (after consulting your doctor) can also be beneficial.
13. How can I reduce stomach upset or nausea when taking the tablets?
Always taking your Imatinib dose with food and a large glass of water is the most effective way to prevent or reduce nausea and stomach irritation.
14. Will I lose my hair while taking Imatinib?
Significant hair loss is uncommon with Imatinib. Some patients may experience mild hair thinning, but it is not the complete hair loss associated with many traditional chemotherapy drugs.
15. Are there any serious side effects to watch out for?
Yes. While less common, serious side effects can include severe fluid retention, heart problems (including congestive heart failure), liver toxicity, severe skin reactions, and low blood cell counts. It’s vital to attend all follow-up appointments for monitoring.
Monitoring, Safety, and Access in the Philippines
16. How will my doctor in the Philippines monitor my treatment?
Your oncologist will monitor you closely with regular blood tests, including a Complete Blood Count (CBC) to check for low blood cells and a PCR test (for CML) to measure the amount of the Bcr-Abl gene, which shows how well the drug is working. Liver function tests will also be performed.
17. Can I take other medications with Imatinib?
You must inform your doctor of all other medications you take, including over-the-counter drugs and supplements. Some drugs, like certain antibiotics or paracetamol (in large doses), can interact with Imatinib.
18. Are there any foods or supplements I should avoid?
Yes, you should avoid grapefruit and grapefruit juice as they can interfere with how your body processes Imatinib, leading to increased side effects.
19. Can Imatinib be taken during pregnancy?
No. Imatinib can cause harm to a developing fetus. Women must not become pregnant while taking this medication and should use effective contraception. Discuss family planning with your oncologist before starting treatment.
20. Who is qualified to prescribe and manage Imatinib treatment in the Philippines?
Imatinib must be prescribed and managed by a qualified Medical Oncologist or Hematologist, who has expertise in treating leukemia and other cancers.
21. Is Imatinib very expensive in the Philippines?
The list price of Imatinib, especially the innovator brand, can be very high. However, due to several assistance programs and the availability of generics, access is possible for many Filipino patients.
22. What is the GIPAP program and how can Filipino patients apply for it?
The Glivec International Patient Assistance Program (GIPAP) is a globally recognized program run by the drug’s manufacturer, Novartis, in partnership with The Max Foundation. It provides Imatinib (Glivec®) for free to eligible, financially-disadvantaged patients with CML and GIST in the Philippines. Your oncologist can help you determine your eligibility and guide you through the application process.
23. Does PhilHealth provide coverage for Imatinib treatment?
Yes, the Philippine Health Insurance Corporation (PhilHealth) offers the Z Benefit Package for Catastrophic Illnesses, which includes coverage for certain types of leukemia like CML. This package can help significantly reduce the out-of-pocket costs for diagnostic tests and treatment.
24. Where can patients access Imatinib and related care in the Philippines?
Treatment is managed through major hospitals and cancer centers in the Philippines with specialized oncology and hematology departments. Access to programs like GIPAP is typically facilitated through these designated medical institutions.
25. What kind of support is available for patients on long-term Imatinib therapy?
In the Philippines, patient support groups provide invaluable emotional and practical support. Groups like Toughest Mnl (formerly The CML Society of the Philippines) offer a community for patients and their families to share experiences and find encouragement.
Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice. Imatinib is a prescription medication. Always consult your oncologist or hematologist for diagnosis, treatment, and any questions you may have regarding your medical condition.
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